Kun Qu
1、Develops new genomics sequencing technology and biological big data analysis algorithms and software by interdisciplinary approach of biology, chemistry, mathematics and computer science, and provide various tools for solving complex problems in the field of biomedical science.
(1).Developed ftATAC-seq technology and APEC algorithm to accurately obtain and analyze single cell chromatin accessibility
(2).Developed WEDGE algorithm to accurately recover missing information on gene expression in single-cell transcriptome sequencing data
(3).Developed ATAC-pipe software to quickly analyze genome chromatin accessibility sequencing data information
(4).Developed GenomeSpace software system to implement cloud-based online bioinformatics analysis
(5).Developed PIRCh-seq technology to systematic study RNA and chromatin interactions
This work was published in Genome Biology (2020, 2019), Briefings in Bioinformatics (21, 2019), and Nature Methods (2016).
2、Reveals the immunological pathogenic mechanism of major diseases by interdisciplinary approach of biology, medicine and computer science, using various existing and original tools.
(1).Discovered the cytokine storm and immune response mechanisms at single-cell level in patients with severe COVID-19
(2).Discovered the dynamic processes and molecular mechanisms of response to anticancer drugs in patients with cutaneous T-cell lymphoma
(3).Discovered a new mechanism by which dendritic cell-mediated immune abnormalities lead to systemic sclerosis
(4).Discovered a new mechanism by which monocytes mediated immune abnormalities lead to rheumatoid arthritis
This work was published in Published in Cell (2021), Cancer Cell (2017), Nature Communications (2020A, 2020B), Cell Discovery (2021), BMC Biology (2021)