科研成果

研究成果（2021-2007）

2021

  1. Yan Hao, Yanjuan Li, Lei Song, Zhaoxiang Deng*, Flash Synthesis of Spherical Nucleic Acids with Record DNA Density, J. Am. Chem. Soc. 2021, 143, 3065-3069 (doi: 10.1021/jacs.1c00568)

  2. Xianwen Ren*, Wen Wen*, Xiaoying Fan*, Wenhong Hou*, Bin Su*, Pengfei Cai*, Jiesheng Li*, Yang Liu*, Fei Tang*, Fan Zhang*, Yu Yang*, Jiangping He*, Wenji Ma*, Jingjing He*, Pingping Wang*, Qiqi Cao, Fangjin Chen, Yuqing Chen, Xuelian Cheng, Guohong Deng, Xilong Deng, Wenyu Ding, Yingmei Feng, Rui Gan, Chuang Guo, Weiqiang Guo, Shuai He, Chen Jiang, Juanran Liang, Yi-min Li, Jun Lin, Yun Ling, Haofei Liu, Jianwei Liu, Nianping Liu, Shu-Qiang Liu, Meng Luo, Qiang Ma, Qibing Song, Wujianan Sun, GaoXiang Wang, Feng Wang, Ying Wang, Xiaofeng Wen, Qian Wu, Gang Xu, Xiaowei Xie, Xinxin Xiong, Xudong Xing, Hao Xu, Chonghai Yin, Dongdong Yu, Kezhuo Yu, Jin Yuan, Biao Zhang, Peipei Zhang*, Tong Zhang, Jincun Zhao, Peidong Zhao, Jianfeng Zhou, Wei Zhou, Sujuan Zhong, Xiaosong Zhong, Shuye Zhang, Lin Zhu, Ping Zhu, Bin Zou, Jiahua Zou, Zengtao Zuo, Fan Bai, Xi Huang, Penghui Zhou#, Qinghua Jiang#, Zhiwei Huang#, Jin-Xin Bei#, Lai Wei#, Xiu-Wu Bian#, Xindong Liu#, Tao Cheng#, Xiangpan Li#, Pingsen Zhao#, Fu-Sheng Wang#, Hongyang Wang#, Bing Su#, Zheng Zhang#, Kun Qu#, Xiaoqun Wang#, Jiekai Chen#, Ronghua Jin#, Zemin Zhang# “COVID-19 immune features revealed by a large-scale single cell transcriptome atlas ”, Cell , 2021.

  3. Dandan Zong*, Beibei Huang*, Young Li#, Yichen Lu, Nan Xiang, Chuang Guo, Qian Liu, Qing Sha, Pengcheng Du, Qiaoni Yu, Wen Zhang, Pengfei Cai, Yanping Sun, Jinhui Tao, Xiaomei Li#, Shanbao Cai#, Kun Qu# “Chromatin accessibility landscapes of immune cells in rheumatoid arthritis nominate monocytes in disease pathogenesis”, BMC Biology, 2021.

  4. Yinlei Hu*, Bin Li*, Wen Zhang, Nianping Liu, Pengfei Cai, Falai Chen#, Kun Qu# “WEDGE: imputation of gene expression values from single-cell RNA-seq datasets using biased matrix decomposition”, Briefings in Bioinformatics, 2021.

  5. Young Li*, Kun Li*, Lianbang Zhu, Bin Li, Dandan Zong, Pengfei Cai, Chen Jiang, Pengcheng Du, Jun Lin, Kun Qu# “Development of double-positive thymocytes at single-cell resolution”, Genome Medicine, 2021.

  6. Chuang Guo*, Pengfei Cai*, Liying Jin*, Qing Sha, Qiaoni Yu, Wen Zhang, Chen Jiang, Qian Liu, Dandan Zong, Kun Li, Jingwen Fang, Fangting Lu, Yanshi Wang, Daojing Li, Jun Lin, Lu Li, Zhutian Zeng, Xianhong Tong, Haiming Wei, Kun Qu# “Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss”, Cell Discovery, 2021.

  7. Zhao Y, Liu S, Zhou Y, Zhang M, Chen H, Eric Xu H, Sun D, Liu L, Tian C. Structural basis of human α7 nicotinic acetylcholine receptor activation. Cell Res. 2021 Jun;31(6):713-716.

  8. Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C. Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca2+ ions and L-tryptophan. Cell Res. 2021 Apr;31(4):383-394.

  9. Yu L, Fang W, He Y, Cai W, Wei W, Tian C. Secondary structure and transmembrane topology analysis of the N-terminal domain of the inner membrane protein EccE1 from M. smegmatis using site-directed spin labeling EPR. Biochim Biophys Acta Biomembr. 2021 Feb 1;1863(2):183515. 


2020

  1. Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun,  Jinghong Li*, Ultrasound activated polarization of microglia fused with platelet microvesicles for targeted ischemic stroke therapy, Angew. Chem. Inter. Ed., 10.1002/anie.202010391

  2. Ningqiang Gong, Yuxuan Zhang, Xucong Teng, Yongchao Wang, Shuaidong Huo, Guangchao Qing, Qiankun Ni, Xianlei Li, Jinjin Wang, Xiaoxia Ye, Tingbin Zhang, Shizhu Chen, Yongji Wang, Jie Yu, Paul C. Wang, Yaling Gan, Jinchao Zhang, Jinghong Li*, XingJie Liang*, Proton-driven transformable nanovaccine (p-TV) for cancer immunotherapy, Nat. Nanotechnol., 2020, 15, 1053–1064

  3. Kaixiang Zhang, Ruijie Deng, Hua Gao, Xucong Teng, Jinghong Li*, Lightening Up Single-Nucleotide Variation in situ in Single Cells and Tissues, Chem. Soc. Rev., 2020, 49, 1932-1954

  4. Yongji Wang, Ningqiang Gong, Qichen Lu, Yujie Li, Xun Wang, Jinghong Li*, Atomic-level Nanorings (A-NRs) therapeutic agent for photoacoustic imaging and photothermal/photodynamic therapy of cancer, Journal of the American Chemical Society, 2020, 142, 1735-1739

  5. Xiaolin Niu, Qiuhan Liu, Zhonghe Xu, Zhifeng Chen, Linghui Xu, Lilei Xu, Jinghong Li*, Xianyang Fang*, Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs), Nature Communications, 2020, 11, 5496

  6. MH Zhuang, ZH Hou, PY Chen, GL Liang, GM Huang*,Chem. Sci.,2020, 11, 7308-7312

  7. Qian Liu*, Lisa C. Zaba*, Ansuman T. Satpathy, Michelle Longmire, Wen Zhang, Kun Li, Jeffrey Granja, Chuang Guo, Jun Lin, Rui Li, Karen Tolentino, Gabriela Kania, Oliver Distler, David Fiorentino, Lorinda Chung, Kun Qu# & Howard Y. Chang# “Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis”, Nature Communications, 2020.

  8. Chuang Guo*, Bin Li*, Huan Ma, Xiaofang Wang, Pengfei Cai, Qiaoni Yu, Lin Zhu, Liying Jin, Chen Jiang, Jingwen Fang, Qian Liu, Dandan Zong, Wen Zhang, Yichen Lu, Kun Li, Xuyuan Gao, Binqing Fu, Lianxin Liu, Xiaoling Ma, Jianping Weng, Haiming Wei, Tengchuan Jin#, Jun Lin# & Kun Qu# “Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm”, Nature Communications, 2020.

  9. Bin Li*, Young Li*, Kun Li, Lianbang Zhu, Qiaoni Yu, Pengfei Cai, Jingwen Fang, Wen Zhang, Pengcheng Du, Chen Jiang, Jun Lin & Kun Qu# “APEC: an accesson-based method for single-cell chromatin accessibility analysis”, Genome Biology, 2020.

  10. Haohuan Xie*, Wen Zhang*, Mei Zhang*#, Tasneem Akhtar, Young Li, Wenyang Yi, Xiao Sun, Zuqi Zuo, Min Wei, Xin Fang, Ziqin Yao, Kai Dong, Suijuan Zhong, Qiang Liu, Yong Shen, Qian Wu, Xiaoqun Wang, Huan Zhao, Jin Bao, Kun Qu# & Tian Xue# “Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoids”, Science Advances, 2020.

  11. Sun D, Liu S, Li S, Zhang M, Yang F, Wen M, Shi P, Wang T, Pan M, Chang S, Zhang X, Zhang L, Tian C, Liu L. Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1. Elife. 2020 Sep 11;9:e57096. doi: 10.7554/eLife.57096

  12. Li S, Yang F, Sun D, Zhang Y, Zhang M, Liu S, Zhou P, Shi C, Zhang L, Tian C. Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis. Cell Res. 2020 Nov;30(11):1049-1052. doi: 10.1038/s41422-020-00407-3.

  13. Shi P , Zhang Y , Lv P , Fang W , Ling S , Guo X , Li D , Liu S , Sun D , Zhang L , Liu D , Zheng JS , Tian C . A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET. Chem Commun (Camb). 2020 Jun 25;56(51):6941-6944.

  14. Qu Q, Gao S, Wu F, Zhang MG, Li Y, Zhang LH, Bierer D, Tian CL, Zheng JS, Liu L. Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy. Angew Chem Int Ed Engl. 2020 Apr 6;59(15):6037-6045.

  15. Fan Yang#, Shenglong Ling#, Yingxin Zhou#, Yanan Zhang, Pei Lv, Sanling Liu, Wei Fang, Wenjing Sun, Liaoyuan A. Hu, Longhua Zhang, Pan Shi*, Changlin Tian*. Different conformational Responses of the β2-Adrenergic Receptor-Gs Complex upon Binding of the Partial Agonist Salbutamol or the Full Agonist Isoprenaline. National Science Review. 2020. doi.org/10.1093/nsr/nwaa284.


2019

  1. Ningqiang Gong,Xiaowei Ma, Xiaoxia Ye, Qunfang Zhou, Xiaoli Tan, Shengkun Yao, Shuaidong Huo, Tingbin Zhang, Shizhu Chen, Xucong Teng, Xixue Hu, Jie Yu, Yaling Gan, Huaidong Jiang, Jinghong Li*, Xing-Jie Liang*, Carbon dot-supported atomically-dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment,Nature Nanotechnol., 2019, 14, 379-387

  2. Kaixiang Zhang, Hua Gao, Ruijie Deng, Jinghong Li*, Emerging Application of Nanotechnology for Control of Cell Surface Receptors Clustering,Angew. Chem. Inter. Ed., 2019, 58, 4790-4799

  3. Yulin Li, Zhaoxiang Deng*, Ag Ion Soldering: An Emerging Tool for Sub-nanomeric Plasmon Coupling and Beyond, Acc. Chem. Res. 2019, 52, 3442-3454 (doi: 10.1021/acs.accounts.9b00463)

  4. YT Chen, GY Li, SM Yuan, Y Pan, YZ Liu, GM Huang*，Anal. Chem., 2019,91(16),10441-10447

  5. XQ. Wang#, YW. Hou#, ZH. Hou, W. Xiong*, GM. Huang*. Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization, Anal. Chem., 2019, 91(4), 2719−2726.

  6. Y Li, M Buerkle, G Li, A Rostamian, H Wang, Z Wang, D Bowler, T Miyazaki, L Xiang, Y Asai*, G Zhou* and N Tao*. Gate Controlling of Quantum Interference and Direct Observation of Anti-resonances in Single Molecule Charge Transport. Nature Materials 2019: 18, 357-363.

  7. Y Li, H Wang, Z Wang, Y Qiao, J Ulstrup, H Chen*, G Zhou*, and N Tao*. Transition from stochastic events to deterministic ensemble average in electron transfer reactions revealed by single molecule conductance measurement. Proc. Natl. Acad. Sci. U.S.A. 2019: 116, 3407-3412.

  8. [co-first author] J Tang, Y Li, Q Wu, Z Wang, S Hou, K Tang, Y Sun, H Wang, H Wang, C Lu, X Wang, X Li, D Wang, J Yao, CJ Lambert*, N Tao*, Y Zhong* & PJ. Stang* Single-molecule level control of host-guest interactions in metallocycle-C60 complexes. Nature Communications. 2019: 10, 4599.

  9. Liang J, Gong Q, Li Y, Zheng Y, Zheng JS, Tian C, Li JB. Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition. Chem Commun (Camb). 2019 Oct 17;55(84):12639-12642.

  10. Chu GC, Pan M, Li J, Liu S, Zuo C, Tong ZB, Bai JS, Gong Q, Ai H, Fan J, Meng X, Huang YC, Shi J, Deng H, Tian C, Li YM, Liu L. Cysteine-Aminoethylation-Assisted Chemical Ubiquitination of Recombinant Histones. J Am Chem Soc. 2019 Feb 27;141(8):3654-3663.


2018

  1. Kaixiang Zhang, Ruijie Deng, Xucong Teng, Yue Li, Yupeng Sun, Xiaojun Ren, Jinghong Li*, Direct Visualization of Single Nucleotide Variation in Mitochondrial DNA using CRISPR/Cas9 Mediated Proximity Ligation Assay,J. Am. Chem. Soc.,2018, 140, 11293−11301

  2. Lingling Fang, Dilong Liu, Yueliang Wang, Yanjuan Li, Lei Song, Ming Gong, Yue Li*, Zhaoxiang Deng*, Nanosecond-Laser-Based Charge Transfer Plasmon Engineering of Solution-Assembled Nanodimers, Nano Lett. 2018, 18, 7014-7020 (doi: 10.1021/acs.nanolett.8b02965)

  3. Yongfei Li, Lei Song, Bang Wang, Jianbo He, Yulin Li*, Zhaoxiang Deng*, Chengde Mao*, Universal pH-Responsive and Metal-Ion-Free Self-Assembly of DNA Nanostructures, Angew. Chem. Int. Ed. 2018, 57, 6892-6895 (doi: 10.1002/anie.201804054)

  4. HY. Zhu#, N. Wang#, L. Yao, Q. Chen, R. Zhang, JC. Qian, YW. Hou, WW. Guo, SJ. Fan, SL. Liu, QY. Zhao, F. Du, X. Zuo, YJ. Guo, Y. Xu, JL. Li, T. Xue, K. Zhong, XY. Song, GM. Huang*, X. Wei*. Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain, Cell, 2018, 173(7), 1716-1727.

  5. GY. Li#, SH. Zheng#, YT. Chen, ZH. Hou, GM. Huang*. Reliable Tracking In-Solution Protein Unfolding via Ultrafast Thermal Unfolding/Ion Mobility-Mass Spectrometry, Anal. Chem., 2018, 90(13), 7997−8001.

  6. GY. Li#, SM. Yuan#, SH. Zheng, YZ. Liu*, GM. Huang*. In Situ Living Cell Protein Analysis by Single-Step Mass Spectrometry, Anal. Chem., 2018, 90(5), 3409-3415.

  7. H Wang, Z Wang, Y Wang, J Hihath, H Chen*, Y Li*, and N Tao*. Potential Dependence of Mechanical Stability and Electronic Coupling of Single S–Au Bonds. J. Am. Chem. Soc., 2018, 140 (51): 18074–18081.

  8. R Sha, L Xiang, C Liu, A Balaeff, Y Zhang, P Zhang, Y Li, D N Beratan*, N Tao*, N C Seeman*. Charge splitters and charge transport junctions based on guanine quadruplexes. Nature Nanotechnology. 2018:13,316-321.

  9. Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F, Wang Q, Rao Z. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science. 2018 Nov 30;362(6418):eaat8923.

  10. Li JB, Qi YK, He QQ, Ai HS, Liu SL, Wang JX, Zheng JS, Liu L, Tian C. Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes. Cell Res. 2018 Feb;28(2):262.


2017

  1. HY. Zhu#, GC. Zou#, N. Wang#, MH. Zhuang, W. Xiong*, GM. Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry, Proc. Natl. Acad. Sci. U.S.A.(PNAS), 2017, 114(10), 2586-2591.

  2. Y Li, N Haworth, L Xiang, S Ciampi*, M Coote*, and N Tao*. Mechanical stretching-induced electron transfer reactions and conductance switching in single molecules. J. Am. Chem. Soc., 2017, 139 (41): 14699–14706.

  3. L Xiang, J L Palma, Y Li, V Mujica, M A Ratner, N Tao*. Gate-controlled conductance switching in DNA. Nature Communications. 2017: 8, 14471.


2016

  1. Lingling Fang, Yueliang Wang, Miao Liu, Ming Gong, An Xu, Zhaoxiang Deng*, Dry Sintering Meets Wet Silver-Ion "Soldering": Charge-Transfer Plasmon Engineering of Solution-Assembled Gold Nanodimers From Visible to Near-Infrared I and II Regions, Angew. Chem. Int. Ed. 2016, 55, 14296-14300 (doi: 10.1002/anie.201608271)

  2. GY. Li, SM. Yuan, Y. Pan, YZ. Liu, GM. Huang*. Binding States of Protein–Metal Complexes in Cells, Anal. Chem., 2016, 88(22), 10860-10866.

  3. Y Li, L Xiang, JL Palma, Y Asai, and N Tao*. Thermoelectric effect and its dependence on molecular length and sequence in single DNA molecules. Nature Communications. 2016, 7: 11294.

  4. C Liu, L Xiang, Y Zhang, P Zhang, D N Beratan*, Y Li, N Tao*. Engineering nanometre-scale coherence in soft matter. Nature Chemistry. 2016: 8, 941-945.


2015

  1. C Bruot, L Xiang, J L Palma, Y Li, N Tao*. Tuning the electromechanical properties of single DNA molecular junctions. J. Am. Chem. Soc., 2015, 137 (41): 13933–13937.


2014

  1. Ying Wang, Longhua Tang, Zhaohui Li, Yuehe Lin, Jinghong Li*, In situ simultaneous monitoring of ATP and GTP using graphene oxide nanosheets-based sensing platform in living cells, Nature Protocol, 2014, 9, 1944-1955

  2. Huiqiao Wang, Yulin Li, Ming Gong, Zhaoxiang Deng*, Core solution: a strategy towards gold core/non-gold shell nanoparticles bearing strict DNA-valences for programmable nanoassembly, Chem. Sci. 2014, 5, 1015-1020 (doi: 10.1039/C3SC52445K)


2012

  1. Xiaonan Shan, Ismael Díez-Pérez, Luojia Wang, Peter Viktor, Ying Gu*, Lihua Zhang, Wei Wang, Jin Lu, Shaopeng Wang, Qihuang Gong, Jinghong Li*, Nongjian Tao*, Imaging the electrocatalytic activity of single nanoparticles, Nature Nanotechnol.,2012, 7, 668-672


2011

  1. GM. Huang, GT. Li, R.G. Cooks*. Induced Nanoelectrospray Ionization for Matrix-Tolerant and High-Throughput Mass Spectrometry, Angew. Chem. Int. Ed., 2011, 123(42), 10081-10084.

  2. GM. Huang, GT. Li, J. Ducan, Z. Ouyang, R.G. Cooks*. Synchronized Inductive Desorption Electrospray Ionization Mass Spectrometry, Angew. Chem. Int. Ed., 2011, 123(11), 2551-2554.


2010

  1. Jinbin Liu, Songhe Fu, Bin Yuan, Yulin Li, Zhaoxiang Deng*, Toward a Universal “Adhesive Nanosheet” for the Assembly of Multiple Nanoparticles Based on a Protein-Induced Reduction/Decoration of Graphene Oxide, J. Am. Chem. Soc. 2010, 132, 7279-7281 (doi: 10.1021/ja100938r)

  2. Huang, Xiong-Yi; Wang, Hua-Jing; Shi, Jing*，Theoretical Study on Acidities of (S)-Proline Amide Derivatives in DMSO and Its Implications for Organocatalysis, The Journal of Physical Chemistry A, 2010,10.1021/JP909043A

  3. Shi, Jing; Huang, Xiong-Yi; Wang, Jun-Peng; Li, Run, A Theoretical Study on C-COOH Homolytic Bond Dissociation Enthalpies, 2010, The Journal of Physical Chemistry A, 10.1021/JP910498Y



2009

  1. Jilin Xia, Fang Chen, Jinghong Li*, Nongjian Tao*, Measurement of the Quantum Capacitance of Graphene, Nature Nanotechnol., 2009, 4, 505-509



2008

  1. Xiaogang Han, Zihao Zhou, Fan Yang, Zhaoxiang Deng*, Catch and release: DNA tweezers that can capture, hold and release an object under control, J. Am. Chem. Soc. 2008, 130, 14414-14415 (doi: 10.1021/ja805945r)


2007

  1. Yulin Li, Xiaogang Han, Zhaoxiang Deng*, Grafting SWNTs with Highly Hybridizable DNA Sequences: Potential Building Blocks for DNA-Programmed Material Assembly, Angew. Chem. Int. Ed. 2007, 46, 7481-7484 (doi: 10.1002/anie.200701748)

  1. Xiaogang Han, Yulin Li, Zhaoxiang Deng*, DNA-Wrapped Single-Walled Carbon Nanotubes as Rigid Templates for Assembling Linear Gold Nanoparticle Arrays, Adv. Mater. 2007, 19, 1518-1522 (doi: 10.1002/adma.200602861)



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